Dopamine Transporter Imaging in Neurological Practice - Glasgow
By Donald Grossett, BSc, MBChB, FRCP, MD
Consultant Neurologist, Institute of Neurological Sciences, Glasgow G51 4TF, and Honorary Senior Lecturer, University of Glasgow
This course, which was held February 5, 2009, was designed to inform delegates of the basic principles of dopamine transporter system, tying this in to functional in vivo imaging and clinical application and evaluation. The study day encompassed several imaging modalities, such as PET and cardiac MIBG, but as would be expected the focus was principally on FP-CIT SPECT (DaTSCAN) in day to day practice.
The theme of the meeting was to combine clinical and imaging approaches in terms of pathophysiological thinking. Delegates were encouraged to consider and develop an understanding of the structure and function of the normal nigrostriatal pathway, and then think of how damage to the presynaptic dopaminergic system might result in clinical problems, which can be analyzed by functional imaging.
While of course much attention was paid to idiopathic Parkinson's disease, the Parkinson plus disorders and cerebrovascular disease, as well as effects of drugs at the postsynaptic dopamine receptor were also discussed. Further, the dementias associated with parkinsonism were reviewed, in particular Lewy body dementia versus Alzheimer's disease.
The City Chambers is located in the very heart of Glasgow and is one of the city's most important and prestigious buildings.
The venue was the Radisson SAS Hotel in Glasgow, a recently completed and award-winning building in an urban regenerated area in the city centre. The audience consisted of neurology clinicians, Parkinson's disease nurse specialists, and imaging specialists, from locally within west Scotland but also farther afield in the United Kingdom. We were also delighted to welcome delegates from Sweden, Armenia, and Germany, some of whom had received travel awards from The Movement Disorder Society.
Following the layout of similar dopamine transporter workshops which have been undertaken at other European centres, the morning format was of lectures leading into clinical case studies and the afternoon session took a predominantly imaging focus, but conjoined again to the clinical background and interpretation.
If you are involved in the clinical diagnosis of parkinsonism and tremor disorders, and/or the interpretation of dopamine transport functional imaging, and have not yet attended a DTI workshop, you may wish to explore attendance at one of the other workshops in this series.