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Journal CME

Journal CME 36.07: Perampanel Inhibits a-Synuclein Transmission in Parkinson’s Disease Models

Length:60 MinutesCME Credits:1Release Date:Jul 29, 2021

Experienced / IntermediateJournal CME

Program Description

The Journal CME 36.07 article provided an examination of the effect of perampanel, an antiepileptic drug, on α-synuclein transmission in cultured cells and mouse models of Parkinson’s disease.


  • Basic/Translational Neuroscience


Jun Eada, MD

Course Purpose

Journal CME highlights various articles covering relevant issues, developments and research topics in the area of movement disorders. Articles are selected from Movement Disorders, the official Journal of the International Parkinson and Movement Disorder Society.

Learning Objectives

Upon completion of this activity learners will be able to:

  1. Understand the effect of perampanel on α-synuclein transmission in cultured cells and mouse models of PD
  2. Assess how the inhibition of neuronal activity could modulate the dynamics of α-syn, inhibit the propagation of α-syn pathology, and attenuate the progression of PD
  3. Evaluate the targeting of neuronal activity with PER as a new therapeutic strategy for synucleinopathies including PD and other neurodegenerative diseases

Intended Audience

This activity is intended for physicians, fellows or other practitioners in the field of Movement Disorders with an emphasis on current practice trends.

Accreditation Credit

Accreditation Statement

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME). The International Parkinson and Movement Disorder Society is accredited by the ACCME to provide continuing medical education for physicians.


Credit Designation Statement

The International Parkinson and Movement Disorder Society designates this education activity for a maximum of 1.0 AMA PRA Category 1 Credits™. Physicians should claim only credit commensurate with the extent of their participation in the activity.

Method of Participation

Your chosen sessions must be attended in their entirety. Partial credit of individual sessions is not available. If you are seeking continuing education credit for a specialty not listed in the Accreditation Statement, it is your responsibility to contact your licensing/certification board to determine course eligibility for your board requirement.

Faculty Disclosure

All individuals in control of content for this activity are required to disclose all financial relationships with ineligible companies (as defined by the ACCME) over the last 24 months. Disclosure information is available below. All relevant financial relationships have been mitigated in advance of this program.


Sara Schaefer: Course Director
Nothing to Disclose

Veronica Santini: Reviewer
Grant: Insightec, Biogen, Roche / Genentech

Jun Ueda: Author
Nothing to Disclose

Norihito Uemura: Author
Nothing to Disclose

Masanori Sawamura: Author
Nothing to Disclose

Tomoyuki Taguchi: Author
Nothing to Disclose

Masashi Ikuno: Author
Nothing to Disclose

Seiji Kaji: Author
Nothing to Disclose

Yosuke TarunoAuthor
Nothing to Disclose

Shuichi Matsuzawa: Author
Nothing to Disclose

Hodaka Yamakado: Author
Nothing to Disclose

Ryosuke Takahashi: Author
Nothing to Disclose

Staff Disclosure

MDS staff members involved with the planning, development, and review of the content for this activity have no relevant affiliations or financial relationships to disclose.

Hardware and Software Requirements

1. Active Internet connection (DSL or Cable). Dial-up connection will have constant buffering problem.
2. Compatible with Windows PC and MAC (256 MB of RAM or higher)
3. Activity is best viewed on Internet Explorer 9.0 or higher, Safari 5.0 or higher and Firefox 29.0 or higher
4. Adobe Flash Player 12.0 (or higher).
5. Adobe Reader to print certificate.

Contact Us

MDS Education

MDS Secretariat Liaison

Ericka Blackford


All individuals in control of content for this course are required to disclose all relevant financial relationships with commercial interests as defined by the ACCME.

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