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International Parkinson and Movement Disorder Society
Main Content

Journal CME

Journal CME 37.10: Striatal Blood–Brain Barrier Opening in Parkinson’s Disease Dementia: A Pilot Exploratory Study

Length:60 MinutesCME Credits:1Release Date:Dec 01, 2022

Expert / AdvancedJournal CME

Program Description

The Journal CME 37.10 article provided a report of a phase I clinical trial in Parkinson's disease with dementia to test the safety and feasibility of striatal blood–brain barrier (BBB) opening in PD patients.


  • Parkinson Disease/Hypokinetic Movement Disorders
  • Therapies-Surgical

Course Purpose

The Journal CME 37.10 article provided a report of a phase I clinical trial in Parkinson's disease with dementia to test the safety and feasibility of striatal blood–brain barrier (BBB) opening in PD patients.

Learning Objectives

Upon completion of this activity learners will be able to:

  1. Assess the findings of the study that suggest striatal blood-brain barrier (BBB) opening is feasible, reversible, safe, and well tolerated
  2. Evaluate whether repeated exposure and bilateral interventions are associated with further dopaminergic loss
  3. Examine whether striatal BBB opening reduces striatal ß-amyloid burden

Intended Audience

This activity is intended for clinicians, other health professionals, researchers, policy makers from throughout the world, both MDS members and non-members, who interact with patients living with Movement Disorders.

Accreditation Credit


This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME). The International Parkinson and Movement Disorder Society is accredited by the ACCME to provide continuing medical education for physicians.


The International Parkinson and Movement Disorder Society designates this education activity for a maximum of 1.0 AMA PRA Category 1 Credits™. Physicians should claim only credit commensurate with the extent of their participation in the activity.


Each module will take approximately one (1) hour to complete. Upon reading the article, participants will take a post-test and must receive a grade of 75% or higher to pass. Participants are allowed multiple attempts to complete the post-test. Once the post-test is passed, participants are required to complete the module evaluation.

Method of Participation


Your chosen sessions must be attended in their entirety. Partial credit of individual sessions is not available. If you are seeking continuing education credit for a specialty not listed in the Accreditation Statement, it is your responsibility to contact your licensing/certification board to determine course eligibility for your board requirement.


Participants of this educational program will have the opportunity to claim their CME credits upon completion of the evaluation at the conclusion of the module. Please take time to complete the online evaluations as your input and comments are essential in planning future educational programs. The CME certificate is available immediately following the completion of the module.

Faculty Disclosure


All individuals in control of content for this activity are required to disclose all financial relationships with ineligible companies (as defined by the ACCME) over the last 24 months. Disclosure information is available below. All relevant financial relationships have been mitigated in advance of this program.

Sara Schaefer: Course Director

Nothing to Disclose

Sanjay Pandey: Reviewer

Nothing to Disclose

Hardware and Software Requirements

1. Active Internet connection (DSL or Cable). Dial-up connection will have constant buffering problem.

2. Compatible with Windows PC and MAC (256 MB of RAM or higher)

3. Activity is best viewed on Internet Explorer 9.0 or higher, Safari 5.0 or higher and Firefox 29.0 or higher

4. Adobe Flash Player 12.0 (or higher).

5. Adobe Reader to print certificate.

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All recommendations involving clinical medicine in MDS activities are based on evidence that is accepted within the profession of medicine as adequate justification for their indications and contraindications in the case of patients. All scientific research referred to, reported or used in CME in support or justification of a patient care recommendations conforms to the generally accepted standards of experimental design, data collection and analysis. Activities that promote recommendations, treatment or manners of practicing medicine not within the definition of CME or are knowing to have risks or dangers that outweigh the benefits or are knowing to be ineffective in the treatment of patients do not constitute valid CME.

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