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International Parkinson and Movement Disorder Society
Main Content

Journal CME

Journal CME 37.10: Striatal Blood–Brain Barrier Opening in Parkinson’s Disease Dementia: A Pilot Exploratory Study

Length:60 MinutesCME Credits:1Release Date:Dec 01, 2022

Expert / AdvancedJournal CME

Program Description

The Journal CME 37.10 article provided a report of a phase I clinical trial in Parkinson's disease with dementia to test the safety and feasibility of striatal blood–brain barrier (BBB) opening in PD patients.


  • Parkinson Disease/Hypokinetic Movement Disorders
  • Therapies-Surgical


José A. Pineda-Pardo, PhD

Course Purpose

Journal CME highlights various articles covering relevant issues, developments and research topics in the area of movement disorders. Articles are selected from Movement Disorders, the official Journal of the International Parkinson and Movement Disorder Society.

Learning Objectives

Upon completion of this activity learners will be able to:

  1. Assess the findings of the study that suggest striatal blood-brain barrier (BBB) opening is feasible, reversible, safe, and well tolerated
  2. Evaluate whether repeated exposure and bilateral interventions are associated with further dopaminergic loss
  3. Examine whether striatal BBB opening reduces striatal ß-amyloid burden

Intended Audience

This activity is intended for clinicians, other health professionals, researchers, policy makers from throughout the world, both MDS members and non-members, who interact with patients living with Movement Disorders.

Accreditation Credit

Accreditation Statement

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME). The International Parkinson and Movement Disorder Society is accredited by the ACCME to provide continuing medical education for physicians.

Credit Designation Statement

The International Parkinson and Movement Disorder Society designates this education activity for a maximum of 1.0 AMA PRA Category 1 Credits™. Physicians should claim only credit commensurate with the extent of their participation in the activity.

Method of Participation

Your chosen sessions must be attended in their entirety. Partial credit of individual sessions is not available. If you are seeking continuing education credit for a specialty not listed in the Accreditation Statement, it is your responsibility to contact your licensing/certification board to determine course eligibility for your board requirement.

Faculty Disclosure

All individuals in control of content for this activity are required to disclose all financial relationships with ineligible companies (as defined by the ACCME) over the last 24 months. Disclosure information is available below. All relevant financial relationships have been mitigated in advance of this program.

Vikas Kotagal: Course Director

Nothing to Disclose

Veronica Santini: Reviewer

Grant: Insightec, Biogen, Roche / Genentech

José A. Pineda-PardoAuthor

Nothing to Disclose

Carmen Gasca-SalasAuthor

Nothing to Disclose

Beatriz Fernández-RodríguezAuthor

Nothing to Disclose

Rafael Rodríguez-RojasAuthor

Nothing to Disclose

Marta del ÁlamoAuthor

Nothing to Disclose

Ignacio ObesoAuthor

Nothing to Disclose

Frida Hernández-FernándezAuthor

Nothing to Disclose

Clara TrompetaAuthor

Nothing to Disclose

Raúl Martínez-FernándezAuthor

Nothing to Disclose

Michele MatarazzoAuthor

Nothing to Disclose

David Mata-MarínAuthor

Nothing to Disclose

Pasqualina GuidaAuthor

Nothing to Disclose

Alicia DuqueAuthor

Nothing to Disclose

David AlbilloAuthor

Nothing to Disclose

Isabel Plaza de las HerasAuthor

Nothing to Disclose

Juan I. MonteroAuthor

Nothing to Disclose

Guglielmo FoffaniAuthor

Nothing to Disclose

Gabriella ToltsisAuthor

Employee: Insightec Ltd

Itay RachmilevitchAuthor

Employee: Insightec Ltd

Javier BlesaAuthor

Nothing to Disclose

José A. ObesoAuthor

Nothing to Disclose

Staff Disclosure

MDS staff members involved with the planning, development, and review of the content for this activity have no relevant affiliations or financial relationships to disclose.

Hardware and Software Requirements

1. Active Internet connection (DSL or Cable). Dial-up connection will have constant buffering problem.

2. Compatible with Windows PC and MAC (256 MB of RAM or higher)

3. Activity is best viewed on Internet Explorer 9.0 or higher, Safari 5.0 or higher and Firefox 29.0 or higher

4. Adobe Flash Player 12.0 (or higher).

5. Adobe Reader to print certificate.

Contact Us

MDS Education

MDS Secretariat Liaison

Nick Bauman


All individuals in control of content for this course are required to disclose all relevant financial relationships with commercial interests as defined by the ACCME.

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