Skip to Content


MDS makes every effort to publish accurate information on the website. "Google Translate" is provided as a free tool for visitors to read content in one's native language. Translations are not guaranteed to be 100% accurate. Neither MDS nor its employees assume liability for erroneous translations of website content.

International Parkinson and Movement Disorder Society
Main Content

Journal CME

Journal CME 38.11: Autosomal Dominant MPAN: Mosaicism Expands the Clinical Spectrum to Atypical Late-Onset Phenotypes

Length:60 MinutesCME Credits:1Release Date:Nov 20, 2023

Experienced / IntermediateJournal CME

Program Description

The Journal CME 38.11 article provided a summary to characterize the clinical, molecular, and functional spectra associated with such dominant pathogenic heterozygous C19orf12 variants and the relation to mitochondrial membrane protein-associated neurodegeneration (MPAN).


  • Biomarkers & Diagnostic Tools
  • Etiology & Pathophysiology
  • Hyperkinetic Movement Disorders


Chloé Angelini, MD

Course Purpose

Journal CME highlights various articles covering relevant issues, developments and research topics in the area of movement disorders. Articles are selected from Movement Disorders, the official Journal of the International Parkinson and Movement Disorder Society.

Learning Objectives

Upon completion of this activity learners will be able to:

  1. Understand the characterization of the clinical, molecular, and functional spectra associated with such dominant pathogenic heterozygous C19orf12 variants
  2. Assess the cause of mitochondrial membrane protein-associated neurodegeneration (MPAN)
  3. Evaluate the clinical, imaging, and molecular information collected from the patients involved in the study

Intended Audience

This activity is intended for clinicians, other health professionals, researchers, policy makers from throughout the world, both MDS members and non-members, who interact with patients living with Movement Disorders.

Accreditation Credit


This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME). The International Parkinson and Movement Disorder Society is accredited by the ACCME to provide continuing medical education for physicians.


The International Parkinson and Movement Disorder Society designates this education activity for a maximum of 1.0 AMA PRA Category 1 Credits™. Physicians should claim only credit commensurate with the extent of their participation in the activity.


Each module will take approximately one (1) hour to complete. Upon reading the article, participants will take a post-test and must receive a grade of 75% or higher to pass. Participants are allowed multiple attempts to complete the post-test. Once the post-test is passed, participants are required to complete the module evaluation.

Method of Participation


Your chosen sessions must be attended in their entirety. Partial credit of individual sessions is not available. If you are seeking continuing education credit for a specialty not listed in the Accreditation Statement, it is your responsibility to contact your licensing/certification board to determine course eligibility for your board requirement.


Participants of this educational program will have the opportunity to claim their CME credits upon completion of the evaluation at the conclusion of the module. Please take time to complete the online evaluations as your input and comments are essential in planning future educational programs. The CME certificate is available immediately following the completion of the module.

Faculty Disclosure


All individuals in control of content for this activity are required to disclose all financial relationships with ineligible companies (as defined by the ACCME) over the last 24 months. Disclosure information is available below. All relevant financial relationships have been mitigated in advance of this program.

Sara Schaefer: Course Director

Nothing to Disclose

Harini Sarva: Reviewer

Clinical trial support: Insightec, Blue Rock, Prevail, Neuroderm, Biogen, Genentech/Roche, Novo Nordisk, Bukwang

Consulting work:  Novo Nordisk, Blue Rock

Chloé Angelini: Author

Nothing to Disclose

Christelle Marie Durand: Author

Nothing to Disclose

Patricia Fergelot: Author

Nothing to Disclose

Julie Deforges: Author

Nothing to Disclose

Anne Vital: Author

Nothing to Disclose

Patrice Menegon: Author

Nothing to Disclose

Elizabeth Sarrazin: Author

Nothing to Disclose

Rémi BellanceAuthor

Nothing to Disclose

Stéphane MathisAurthor

Nothing to Disclose

Victoria GonzalezAuthor

Nothing to Disclose

Mathilde RenaudAuthor

Nothing to Disclose

Solène Frismand Author

Nothing to Disclose

Emmanuelle SchmittAuthor

Nothing to Disclose

Marie RouanetAuthor

Nothing to Disclose

Lydie BurglenAuthor

Nothing to Disclose

Brigitte ChabrolAuthor

Nothing to Disclose

Béatrice DesnousAuthor

Nothing to Disclose

Benoît ArveilerAuthor

Nothing to Disclose

Giovanni StevaninAuthor

Nothing to Disclose

Isabelle CoupryAuthor

Nothing to Disclose

Cyril GoizetAuthor

Nothing to Disclose

Hardware and Software Requirements

1. Active Internet connection (DSL or Cable). Dial-up connection will have constant buffering problem.

2. Compatible with Windows PC and MAC (256 MB of RAM or higher)

3. Activity is best viewed on Internet Explorer 9.0 or higher, Safari 5.0 or higher and Firefox 29.0 or higher

4. Adobe Flash Player 12.0 (or higher).

5. Adobe Reader to print certificate.

Contact Us

MDS Education



All recommendations involving clinical medicine in MDS activities are based on evidence that is accepted within the profession of medicine as adequate justification for their indications and contraindications in the case of patients. All scientific research referred to, reported or used in CME in support or justification of a patient care recommendations conforms to the generally accepted standards of experimental design, data collection and analysis. Activities that promote recommendations, treatment or manners of practicing medicine not within the definition of CME or are knowing to have risks or dangers that outweigh the benefits or are knowing to be ineffective in the treatment of patients do not constitute valid CME.

We use cookies to give you the best possible experience with our website. These cookies are also used to ensure we show you content that is relevant to you. If you continue without changing your settings, you are agreeing to our use of cookies to improve your user experience. You can click the cookie settings link on our website to change your cookie settings at any time. Note: The MDS site uses related multiple domains, including and This cookie policy only covers the primary and domain. Please refer to the MDS Privacy Policy for information on how to configure cookies for all other domains on the MDS site.
Cookie PolicyPrivacy Notice