Journal CME 38.11: Autosomal Dominant MPAN: Mosaicism Expands the Clinical Spectrum to Atypical Late-Onset Phenotypes

Course Purpose

Journal CME highlights various articles covering relevant issues, developments and research topics in the area of movement disorders. Articles are selected from Movement Disorders, the official Journal of the International Parkinson and Movement Disorder Society.

Learning Objectives

Upon completion of this activity learners will be able to:

1. Understand the characterization of the clinical, molecular, and functional spectra associated with such dominant pathogenic heterozygous C19orf12 variants
2. Assess the cause of mitochondrial membrane protein-associated neurodegeneration (MPAN)
3. Evaluate the clinical, imaging, and molecular information collected from the patients involved in the study

Intended Audience

This activity is intended for clinicians, other health professionals, researchers, policy makers from throughout the world, both MDS members and non-members, who interact with patients living with Movement Disorders.

Accreditation Credit

ACCREDITATION STATEMENT

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME). The International Parkinson and Movement Disorder Society is accredited by the ACCME to provide continuing medical education for physicians.

CREDIT DESIGNATION STATEMENT

The International Parkinson and Movement Disorder Society designates this education activity for a maximum of 1.0 AMA PRA Category 1 Credits™. Physicians should claim only credit commensurate with the extent of their participation in the activity.

SATISFACTORY COMPLETION

Each module will take approximately one (1) hour to complete. Upon reading the article, participants will take a post-test and must receive a grade of 75% or higher to pass. Participants are allowed multiple attempts to complete the post-test. Once the post-test is passed, participants are required to complete the module evaluation.

Method of Participation

METHOD OF PARTICIPATION

Your chosen sessions must be attended in their entirety. Partial credit of individual sessions is not available. If you are seeking continuing education credit for a specialty not listed in the Accreditation Statement, it is your responsibility to contact your licensing/certification board to determine course eligibility for your board requirement.

EVALUATION & CLAIMING CREDIT

Participants of this educational program will have the opportunity to claim their CME credits upon completion of the evaluation at the conclusion of the module. Please take time to complete the online evaluations as your input and comments are essential in planning future educational programs. The CME certificate is available immediately following the completion of the module.

Faculty Disclosure

DISCLOSURE OF FINANCIAL RELATIONSHIPS

All individuals in control of content for this activity are required to disclose all financial relationships with ineligible companies (as defined by the ACCME) over the last 24 months. Disclosure information is available below. All relevant financial relationships have been mitigated in advance of this program.

Sara Schaefer: Course Director

Nothing to Disclose

Harini Sarva: Reviewer

Clinical trial support: Insightec, Blue Rock, Prevail, Neuroderm, Biogen, Genentech/Roche, Novo Nordisk, Bukwang

Consulting work:  Novo Nordisk, Blue Rock

Chloé Angelini: Author

Nothing to Disclose

Christelle Marie Durand: Author

Nothing to Disclose

Patricia Fergelot: Author

Nothing to Disclose

Julie Deforges: Author

Nothing to Disclose

Anne Vital: Author

Nothing to Disclose

Patrice Menegon: Author

Nothing to Disclose

Elizabeth Sarrazin: Author

Nothing to Disclose

Rémi Bellance: Author

Nothing to Disclose

Stéphane Mathis: Aurthor

Nothing to Disclose

Victoria Gonzalez: Author

Nothing to Disclose

Mathilde Renaud: Author

Nothing to Disclose

Solène Frismand Author

Nothing to Disclose

Emmanuelle Schmitt: Author

Nothing to Disclose

Marie Rouanet: Author

Nothing to Disclose

Lydie Burglen: Author

Nothing to Disclose

Brigitte Chabrol: Author

Nothing to Disclose

Béatrice Desnous: Author

Nothing to Disclose

Benoît Arveiler: Author

Nothing to Disclose

Giovanni Stevanin: Author

Nothing to Disclose

Isabelle Coupry: Author

Nothing to Disclose

Cyril Goizet: Author

Nothing to Disclose

Hardware and Software Requirements

1. Active Internet connection (DSL or Cable). Dial-up connection will have constant buffering problem.

2. Compatible with Windows PC and MAC (256 MB of RAM or higher)

3. Activity is best viewed on Internet Explorer 9.0 or higher, Safari 5.0 or higher and Firefox 29.0 or higher

4. Adobe Flash Player 12.0 (or higher).

5. Adobe Reader to print certificate.

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Disclaimer

CONTENT VALIDITY STATEMENT

All recommendations involving clinical medicine in MDS activities are based on evidence that is accepted within the profession of medicine as adequate justification for their indications and contraindications in the case of patients. All scientific research referred to, reported or used in CME in support or justification of a patient care recommendations conforms to the generally accepted standards of experimental design, data collection and analysis. Activities that promote recommendations, treatment or manners of practicing medicine not within the definition of CME or are knowing to have risks or dangers that outweigh the benefits or are knowing to be ineffective in the treatment of patients do not constitute valid CME.