MDS-ES: Misfolding of α-synuclein and tau protein: from basic mechanisms to therapeutic development


Lectures and associated resources available September 30, 2020
Join us live, September 30 from 14:00 – 18:00 CEST



Course Directors

Erwan Bezard, PhD, Wassilios Meissner, MD, PhD


Laura Parkkinen, PhD
Thiago Outeiro, PhD
Maria Grazia Spillantini,FMedSci, FRS
Morvane Colin, PhD
Günter Höglinger, MD, PhD

Course Description

The overall aim of the course is to teach the fundamental mechanisms underlying aggregation and propagation of a-synuclein and tau protein in neurodegenerative movement disorders. Ongoing efforts for the development of therapeutic strategies targeting these two proteins will also be discussed. The course consists of seven virtual lectures given by international experts in the field, followed by an interactive Q&A session to answer the questions of the participants. The course will close with an interactive panel discussion including all experts to address the critical next steps to move the field forward.

The course is part of a broader effort of the International Parkinson and Movement Disorder Society to engage young neurologists and neuroscientists into research on movement disorders and promote translational research involving multidisciplinary approaches.

Interactive Components

Real Time Question and Answer Session (30 minutes) and Real Time Discussion on Critical Next Steps to Move the Field Forward

Target Audience

Young Neurologists and Young Scientists

Learning Objectives 
  1. Describe the prototypical neuropathological lesions observed in synucleinopathies and tauopathies
  2. Recognize the complex mechanisms underlying pathological aggregation of a-synuclein and tau protein
  3. Debate the putative role of distinct a-synuclein and tau species/strains for disease phenotypes and progression
  4. Discuss ongoing efforts towards the development of therapies targeting a-synuclein or tau protein

Lectures and discussion begin September 30 at 14:00 CEST

 Welcome and Course Introduction
 Erwan Bezard and Wassilios Meissner

 Neuropathology in Synucleinopathies and Tauopathies
 Laura Parkkinen

 Mechanisms Underlying Protein Aggregation in Synucleinopathies
 Tiago Outeiro

 Mechanisms Underlying Protein Aggregation in Tauopathies
 Maria Grazia Spillantini

 Propagation of α-synucleinopathy
 Erwan Bezard

 Spreading of Tauopathies
 Morvane Colin

 Therapeutic Strategies Targeting α-synuclein: From Bench to Bed
 Wassilios Meissner

 Therapeutic Strategies Targeting Tau Protein: From Bench to Bed
 Günther Höglinger

 Interactive Question and Answer Session
 All Faculty

 Critical Next Steps to Move the Field Forward
 Discussion between faculty and participants

 Concluding Remarks
 Erwan Bezard and Wassilios Meissner


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