We describe a 78-year-old female without neurological disorders in child or adulthood. When first observed, she complained of forgetfulness for 1 year, without major impairment in everyday life. She also presented extreme sadness, anxiety, and hopelessness. Neuropsychological evaluation disclosed subtle changes in executive functioning and other cognitive domains (attention, psychomotor speed, language, and verbal memory). Neurological examination was normal. A depressive syndrome was diagnosed and she was started on sertraline 50 mg/day. One month later, she developed involuntary movements characterized by an abnormal cervical posture with neck extension, eyebrow elevation, shoulder shrug, gasping, and throat clearing noises (see Video, Segment 1). The patient was able to voluntarily suppress all movements, with rising inner tension and subsequent explosion of involuntary movements and sounds. While not suppressing, she could improve the cervical posture by placing her hand on the chin (see Video, Segment 1). On clinical grounds, the movement disorder present was a tic disorder characterized by dystonic, clonic, and phonic tics. Sertraline was discontinued with major improvement (see Video, Segment 2). Even though a causal relation between sertraline and tics was suspected, an investigation to exclude other causes of adult-onset tics was conducted. Brain MRI revealed cortical atrophy and small subcortical hyperintense T2 lesions. There were no basal ganglia lesions. Laboratory tests, including complete blood count, renal, liver, and thyroid function, vitamin B12, folic acid, serological reactions for syphilis, and human immunodeficiency virus, were normal/negative. For 1 year, she reported transient reappearance of tics in situations of stress. After her husband deceased, sertraline was reintroduced by her family doctor. One week later, tics reappeared, with moderate severity (see Video, Segment 3). Again, it was discontinued with total clinical resolution (see Video, Segment 4). For the past 18 months, she has not been exposed to sertraline or other SSRIs and has been tics free.