Restless Legs Syndrome

Contributed by Marcelo Merello, MD
Director, Neuroscience Department
Head Movement Disorders Section
Institute for Neurological Research Raul Carrea (FLENI)
Buenos Aires, Argentina

 

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Restless legs syndrome (RLS) is a neurological movement disorder characterized by a compelling urge to move the legs usually accompanied by an uncomfortable and unpleasant sensations.

Symptoms begin or worsen during periods of rest or inactivity, are partially or totally relieved by movement, and are worse in the evening or at night. Despite being a common disorder, RLS is generally underdiagnosed. The prevalence of RLS in the general population is 5%–10%, making it the most common movement disorder.

Prevalence increases with advancing age and the condition is observed more frequently in women. Delayed sleep onset, multiple awakenings, and a reduction in sleep efficiency all contribute to significant sleep disturbance in these patients. RLS can be idiopathic and begin at any age, or secondary to conditions such as, iron deficiency, renal failure, neuropathy, and normal pregnancy.

Although the etiology of RLS is still unclear, evidence suggests that the symptoms result from central dopaminergic dysfunction. Although results should be interpreted with caution, brain-imaging studies have shown abnormal dopamine receptor binding and dopamine hypoactivity. Iron deficiency has also been implicated in the etiology of RLS.

Dopamine agonists and l-dopa have demonstrated efficacy in the management of RLS and in contrast, certain agents that block the dopaminergic system aggravate RLS symptoms. Other known treatments for RLS include gabapentin, benzopdiazepines, and opiates.

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Education

Journal CME
Receive CME credit on a Journal article specific to RLS

Live Activities
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International Congress

Abstracts
Search abstracts on PD submitted to the International Congress (Hong Kong)

Scientific Program
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Teaching and Themed Courses
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Announcements

2018 and 2019
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Supported and Endorsed Meetings
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Publications

Movement Disorders Journal
Find articles on RLS from the MDS Journal

Movement Disorders Clinical Practice
Movement Disorders Clinical Practice is an online journal committed to publishing high-quality, peer reviewed articles related to clinical aspects of movement disorders.

Video Library
Search for videos on RLS in the Movement Disorders Journal supplements (Members Only)

Reviews & Position Papers
View collection of Evidence-Based Medicine reviews and task force papers published in the Movement Disorders Journal

Moving Along
Find articles on RLS in the Moving Along newsletter

Movement Disorders Books
Purchase books on RLS from the bookstore

 

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