: Sebastian Heinzel PhD, Daniela Berg MD, Thomas M. Gasser MD, Honglei Chen MD, Chun Yao MSc, Ronald B. Postuma MD, MSc
This online calculator was built for the purpose of clinical and
research usage only. The results should be interpreted by experienced
neurologist or movement disorder specialists as a reference for
diagnosis. Note that the online calculator will not save or retrieve any
information from your computer. Simply scroll down each box and choose
whatever is appropriate. For specific symptoms and markers you find
further information and instructions when you click on the link in the
symptom/marker name. The results of the risk of prodromal PD will be
calculated and displayed automatically.
It is important to note that the online calculator will not save or
retrieve any information from your computer.
Simply scroll down each box and choose whatever is appropriate. The results will be calcualted and displayed automatically.
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2. Regular Pesticide Exposure:
(i.e., ≥100 episodes of non-occupational exposure)
3. Occupational Solvent Exposure:
4. Consume Caffeinated Bevarage:
(i.e., <3 cups of coffee/6 cups of black tea per-week)
6. Family History of PD (first degree relative)?
7-1. Intermediate Strength Genetic Variants associated with PD
GBA Mutation (for specific mutation subtypes see: Anheim 2012, Neurology)
LRRK2 (p.G2019S) Mutation (Lee 2017, Mov Disord)
7-2. Polygenic Risk Score:
8. Documented Substantia Nigra Hyperechogenicity on Transcranial Ultrasound
(i.e., SN+ corresponds to an uni- or bilateral hyperechogenic area in the SN (>90th percentile of the reference sample))
9. Medical Diagnosis of Type II Diabetes Mellitus
10. Physical Inactivity:
(i.e., <1 hour/week of physical activity causing elevating in breath and heart rate/sweating)
11. Low Plasma Urate (Men)
A. Clinical Non-motor Markers:
A-1.1 Polysomnograph-proven RBD:
A-1.2 Are you able to exclude differential diagnosis when screening for RBD?
Results of screeening for RBD:
(*Differential diagnosis and possible drug-induced/nacrolepsy-related dream enactment should be excluded)
A-2 Excessive Daytime Somnolence:
(* Possible drug-induced or nacrolepsy-related RBD symptom should be excluded)
A-3 Olfactory Loss:
(i.e., total score below age-and-sex-adjusted threshold in a quantitative olfactory test (e.g. Sniffin' Stick, UPSIT or B-SIT)
(i.e., constipation requiring treatment more than once a week, or spontaneous bowel movement frequency less than every other day)
A-5 Urinary Dysfunction:
A-6 Severe Erectile Dysfunction:
A-7 Has a measurement of orthostatic hypotension been performed at the clinic?
A-8 Depression (with/without Anxiety):
(Clinical diagnosis or reaching thresholds of at least moderate depression in depression inventories/questionnaires)
A-9 Global Cognitive Deficit:
(i.e., diagnosed with mild cognitive impairment or score more than 1.5SD below the Age-and-sex-adjusted Norm)
B. Clinical Motor Markers:
B-1 UPDRS III Total Score >3 or MDS UPDRS III Total Score >6 (Physician Examination):
(*Excluding action tremor and potential confounds, such as arthritis)
B-2 Abnormal Quantitative Motor Testing (i.e., < Mean + 1SD):
(Abnormalities of quantitative motor tests according to defined thresholds, with performance 1 standard deviation (SD) below age-adjusted normal values. The motor test must be clearly demonstrably abnormal in clinical PD, with specificity compared to controls of ≥80%. If multiple quantitative motor tests are performed, the individual must score below threshold on ≥50% of them. Uncertain or borderline test results should not be included (use evaluator judgment).)