Clinical Resources

Journal CME 41.01: Cerebrospinal Fluid Proenkephalin Predicts Striatal Atrophy Decades before Clinical Motor Diagnosis in Huntington's Disease

On Demand

60 Minutes

Experienced / Intermediate

1074<p>The Journal CME 41.01 article aims to investigate cross-sectional and longitudinal associations between baseline cerebrospinal fluid (CSF) PENK concentration and regional brain atrophy, compared identified patterns with CSF neurofilament light (NfL), and evaluated PENK and NfL for discriminating between HD Integrated Staging System (HD-ISS) stage 0 versus 1 in a far-from-onset HD gene-expanded (HDGE) cohort.</p>Biomarkers, Biomarkers & Diagnostic Tools, Chorea/Huntingtons Disease (HD), Hyperkinetic Movement DisordersMena Farag, MBBS, MRCP601.00https://education.movementdisorders.org/Detail/1074/Journal-CME-41-01:-Cerebrospinal-Fluid-Proenkephalin-Predicts-Striatal-Atrophy-Decades-before-Clinical-Motor-Diagnosis-in-Huntington's-Diseasehttps://education.movementdisorders.org/Upload/ActivityImages/Journal-CME562837664663.jpg2026-02-11T00:00:002027-02-11T00:00:00<p><strong>ACCREDITATION STATEMENT</strong></p><p>This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME). The International Parkinson and Movement Disorder Society is accredited by the ACCME to provide continuing medical education for physicians.</p><p><br></p><p><strong>CREDIT DESIGNATION STATEMENT</strong></p><p>The International Parkinson and Movement Disorder Society designates this activity for a maximum of 1 <em>AMA PRA Category 1 Credits&trade;</em>. Physicians should only claim credit commensurate with the extent of their participation.</p><p><br></p><p><strong>FACULTY DISCLOSURE</strong></p><p>All individuals in control of content for this activity are required to disclose all financial relationships with ineligible companies (as defined by the ACCME) over the last 24 months. Disclosure information is available <a href="https://d1t84l7yt030ad.cloudfront.net/FroalaFiles/Journal%20CME%2041.01%20-%20Disclosures_06022026033938.pdf" rel="noopener noreferrer" target="_blank"><u>HERE</u></a>. All relevant financial relationships have been mitigated in advance of this program.</p><p><br></p><p><strong>METHOD OF PARTICIPATION</strong></p><p>Each module will take approximately one (1) hour to complete. Upon reading the article, participants will take a post-test and must receive a grade of 75% or higher to pass. Participants are allowed multiple attempts to complete the post-test. Once the post-test is passed, participants are required to complete the module evaluation.</p><p><br></p><p><strong>SATISFACTORY COMPLETION</strong></p><p>Participants must complete an evaluation for each session they attend to receive continuing medical education credit. Your chosen session(s) must be attended in their entirety. Partial credit for individual sessions is not available.</p><p><br></p><p><strong>CONTENT VALIDITY STATEMENT</strong></p><p>All recommendations involving clinical medicine in MDS activities are based on evidence that is accepted within the profession of medicine as adequate justification for their indications and contraindications in the case of patients. All scientific research referred to, reported or used in CME in support or justification of a patient care recommendations conforms to the generally accepted standards of experimental design, data collection and analysis. Activities that promote recommendations, treatment or manners of practicing medicine not within the definition of CME or are knowing to have risks or dangers that outweigh the benefits or are knowing to be ineffective in the treatment of patients do not constitute valid CME.</p>MDS Education<p><strong>COURSE PURPOSE</strong></p><p>Journal CME highlights various articles covering relevant issues, developments and research topics in the area of movement disorders. Articles are selected from Movement Disorders, the official Journal of the International Parkinson and Movement Disorder Society.</p><p><br></p><p><strong>LEARNING OBJECTIVES</strong></p><p>Upon completion of this activity, learners will be able to:</p><p>1. Understand the biological rationale for CSF proenkephalin as a striatum-specific biomarker in Huntington&rsquo;s disease<br>2. Assess associations between baseline CSF PENK and longitudinal regional brain atrophy compared with neurofilament light<br>3. Evaluate the role of CSF PENK in distinguishing early HD-ISS stages and its potential value for clinical trial enrichment<br><br></p><p><strong>INTENDED AUDIENCE</strong></p><p>This activity is intended for clinicians, other health professionals, researchers, policy makers from throughout the world, both MDS members and non-members, who interact with patients living with Movement Disorders.</p><p><br></p><p><strong>HARDWARE AND SOFTWARE REQUIREMENTS</strong></p><p>1. Active Internet connection (DSL or Cable). Dial-up connection will have constant buffering problem.</p><p>2. Compatible with Windows PC and MAC (256 MB of RAM or higher).</p><p>3. Activity is best viewed on Internet Explorer 9.0 or higher, Safari 5.0 or higher and Firefox 29.0 or higher.</p><p>4. Adobe Flash Player 12.0 (or higher).</p><p>5. Adobe Reader to print certificate.</p>0/Courses/Journal-CME-41.01-Cerebrospinal-Fluid-Proenkephalin-Predicts-Striatal-Atrophy-Decades-before-Clinical-Motor-Diagnosis-in-Huntingtons-Disease.htmJournal CME 41.01: Cerebrospinal Fluid Proenkephalin Predicts Striatal Atrophy Decades before Clinical Motor Diagnosis in Huntington's DiseaseJournal CME 41.012026-02-11T12:01:11.93000Experienced / IntermediateOn-DemandBiomarkers &amp; Diagnostic ToolsHyperkinetic Movement Disorders

Tremor from Basic Science to Clinical Diagnosis and Therapy

In-Person

Salerno

Sep 18, 2026 - Sep 19, 2026

Experienced / Intermediate

1073During the <em>MDS-ES Tremor from Basic Science to Clinical Diagnosis and Therapy</em> course, evidence based results and speakers&rsquo; experiences will be reviewed from the basic science and clinical points of view and will incorporate talks about newer perspective on tremor measurement with digital/AI assisted tools. Moreover, therapeutic options will be reviewed in depth, from pharmacological treatments to surgical procedures (including DBS and MRgFUS) to alternative options. Two interactive video-case sessions will be included to precipitate further discussion.Basic/Translational Neuroscience, Biomarkers, Biomarkers & Diagnostic Tools, Botulinum toxin, Clinical Trials, Deep brain stimulation, Dopaminergic medications, Etiology & Pathophysiology, Focused Ultrasound, Gene Therapies, Genetics, Hyperkinetic Movement Disorders, Infusion therapy, Medications for motor complications, Medications for motor symptoms, Medications for non-motor symptoms, Neuroimaging, Neuropathology, Rating Scales, Therapies-Pharmacological, Therapies-Surgical, Tremor/Essential Tremor (ET)7500.00https://education.movementdisorders.org/Detail/1073/MDS-ES-Tremor-from-Basic-Science-to-Clinical-Diagnosis-and-Therapyhttps://education.movementdisorders.org/Upload/ActivityImages/26ESBASIC_202x108890630.pnghttps://education.movementdisorders.org/Upload/BannerImages/26ESBASIC_734x404532438.jpeg2026-09-18T00:00:002026-09-19T00:00:00Salerno<p><br></p><p><br></p>MDS Education<p><a href="https://d1t84l7yt030ad.cloudfront.net/FroalaFiles/26ESBASIC Course Schedule_no faculty_05022026122550.pdf" rel="noopener noreferrer" target="_blank"><img src="https://s3-us-east-2.amazonaws.com/mds-lms/FroalaFiles/Course schedule_23012024043738.png" style="width: 125px; height: 125px;" class="fr-fic fr-dib"></a><strong>Course Schedule</strong><strong>&nbsp; &nbsp; &nbsp; &nbsp;&nbsp;</strong><a href="https://d1t84l7yt030ad.cloudfront.net/FroalaFiles/Faculty Listing_LMS_CDs_05022026123017.pdf" rel="noopener noreferrer" target="_blank"><img src="https://s3-us-east-2.amazonaws.com/mds-lms/FroalaFiles/Faculty Details_23012024043924.png" style="width: 125px; height: 125px;" class="fr-fic fr-dib"></a><strong>Course Faculty</strong></p><p><br></p><p><em>Schedule as of February 5, 2026&nbsp;</em></p><p><strong><em><span style="color: rgb(184, 49, 47);">Application Deadline:</span>&nbsp;</em></strong><em>&nbsp;July 1, 2026</em></p><p><br></p><p><strong>REGISTRATION FEES</strong><br><strong>Members:</strong>&nbsp; $275 USD<br><strong>Members</strong><strong>: Junior / HP / Basic Science / No Fee:</strong>&nbsp;$250 USD<br><strong>Non-Members*:</strong>&nbsp;$325 USD</p><p>*<em>Non-members wishing to apply for MDS Membership to receive the MDS Member rate for this course will need to apply for membership no later than 2 weeks in advance of the close of registration.</em><br><br></p><p><a href="https://s3-us-east-2.amazonaws.com/mds-lms/FroalaFiles/VISA%20STATEMENT%20CANCELLATION%20LANGUAGE_24012024041714.pdf" rel="noopener noreferrer" target="_blank">Click here to view the MDS&nbsp;Regional Course Cancellation Policy &amp; Visa Assistance Information</a></p><p><br></p><p><strong>SCHEDULE OVERVIEW</strong><br>Day 1: Friday, September 18, 2026 from 13:00 - 20:00<br>Day 2: Saturday, September 19, 2026 from 9:00 - 16:30<br><br><strong>COURSE VENUE</strong></p><p>Fondazione EBRIS, Salerno, Italy</p><p><br></p><p><strong>LEARNING OBJECTIVES</strong></p><p>Upon completion of this activity, learners will be able to:&nbsp;</p><p>1. Demonstrate how to assess tremor during patient examination</p><p>2. Associate and interpret outcomes from different sources of tremor assessment (clinical scales, electrophysiology, digital tools)&nbsp;</p><p>3. Plan treatment strategies for tremor syndromes (including pharmacological and surgical options)&nbsp;</p><p><br></p><p><strong>INTENDED AUDIENCE</strong></p><p>This activity is intended for neurologists, neurosurgeons, neuroscientists and general practitioners interested in tremor.</p>Salerno0/Courses/Tremor-from-Basic-Science-to-Clinical-Diagnosis-and-Therapy.htmTremor from Basic Science to Clinical Diagnosis and Therapy2026-02-09T12:01:07.03000Experienced / IntermediateIn-PersonBiomarkers &amp; Diagnostic ToolsEtiology &amp; PathophysiologyHyperkinetic Movement DisordersTherapies-PharmacologicalTherapies-Surgical

School for Young Neurologists

In-Person

Cairo Governorate

May 01, 2026 - May 02, 2026

Foundational / Beginner

1068<p>The MDS-African Section School for Young Neurologists is an opportunity for young neurologists who are interested in specializing in Movement Disorders to receive in-depth instruction from internationally recognized Movement Disorders experts. Students will attend lectures and panel discussions with question-and-answer sessions, will have the opportunity to examine patients with movement disorders, and engage in a differential diagnosis with the international experts.</p><p>&nbsp;</p><p style="text-align:center;"><strong>APPLICATION/BURSARY DEADLINE:</strong> February 20, 2026</p>Biomarkers, Biomarkers & Diagnostic Tools, Botulinum toxin, Clinical Trials, Deep brain stimulation, Dopaminergic medications, Focused Ultrasound, Gene Therapies, Genetics, Infusion therapy, Medications for motor complications, Medications for motor symptoms, Medications for non-motor symptoms, Neuroimaging, Neuropathology, Rating Scales, Therapies-Pharmacological, Therapies-Surgical13200.00https://education.movementdisorders.org/Detail/1068/MDS-AS-School-for-Young-Neurologistshttps://education.movementdisorders.org/Upload/ActivityImages/26AFRSYN_202x108244151.png2026-05-01T00:00:002026-05-02T00:00:00Hilton Cairo Heliopolis, Cairo GovernorateMDS Education<p><strong><a href="https://d1t84l7yt030ad.cloudfront.net/FroalaFiles/LMS Prelim Agenda - 26AFRSYN School for Young Neurologists_09022026103407.pdf" rel="noopener noreferrer" target="_blank"><img src="https://d1t84l7yt030ad.cloudfront.net/FroalaFiles/Course schedule_13052025105320.png" style="width: 125px; height: 125px;" class="fr-fic fr-dib"></a></strong><a href="https://d1t84l7yt030ad.cloudfront.net/FroalaFiles/LMS Prelim Agenda - 26AFRSYN School for Young Neurologists_09022026103407.pdf" rel="noopener noreferrer" target="_blank">&nbsp;<strong>Course Schedule</strong></a><strong>&nbsp;&nbsp;</strong> <a href="https://d1t84l7yt030ad.cloudfront.net/FroalaFiles/26AFRSYN Faculty Listing - NO FACULTY_09022026104631.pdf" rel="noopener noreferrer" target="_blank"><img src="https://s3-us-east-2.amazonaws.com/mds-lms/FroalaFiles/Faculty Details_23012024043924.png" style="width: 125px; height: 125px;" class="fr-fic fr-dib"></a><a href="https://d1t84l7yt030ad.cloudfront.net/FroalaFiles/26AFRSYN Faculty Listing - NO FACULTY_09022026104631.pdf" rel="noopener noreferrer" target="_blank"><strong>Course Faculty</strong></a></p><p><br></p><p><em>Schedule as of January 27, 2026</em></p><p><strong><em><span style="color: rgb(175, 38, 38);">Application/Travel Bursary Deadline:</span> February 20, 2026</em></strong></p><p><br></p><p><strong>REGISTRATION FEES</strong><br><strong>Members:</strong>&nbsp;$25 USD<br><strong>Non-Members*:</strong>&nbsp;$150 USD</p><p>*<em>Non-members wishing to apply for MDS Membership to receive the MDS Member rate for this course will need to apply for membership no later than 2 weeks in advance of the close of registration.</em></p><p><a href="https://s3-us-east-2.amazonaws.com/mds-lms/FroalaFiles/VISA%20STATEMENT%20CANCELLATION%20LANGUAGE_24012024041714.pdf">Click here to view the MDS Regional Course Cancellation Policy &amp; Visa Assistance Information</a></p><p><br></p><p><strong>LEARNING OBJECTIVES</strong></p><p>Upon completion of this activity, learners will be able to:&nbsp;</p><ol><li>Recognize the clinical characteristics of different types of movement disorders in both adults and children.</li><li>Perform a comprehensive assessment, including history taking and neurological examination, of patients with movement disorders.</li><li>Identify the various etiologies underlying different types of movement disorders.</li><li>Recognize best practices in the management of movement disorders, including advanced therapies.</li><li>Develop a structured approach to the use of botulinum toxin for the treatment of dystonia and other movement disorders.</li><li>Recognize challenges in the management of patients with movement disorders in Africa and tailor treatment strategies to individual patient needs.</li></ol><p><br></p><p><strong>INTENDED AUDIENCE</strong></p><p>The MDS-AS School for Young Neurologists is intended for young neurologists within five years of their completion of general neurological training who are interested in specializing in movement disorders, and young neurologists who are already training in movement disorders.</p>Cairo Governorate0/Courses/School-for-Young-Neurologists2.htmSchool for Young Neurologists2026-02-05T15:01:06.97000Foundational / BeginnerIn-PersonBiomarkers &amp; Diagnostic ToolsTherapies-PharmacologicalTherapies-Surgical

School for Device Aided Therapies in Parkinson’s Disease

In-Person

Bangkok

May 06, 2026 - May 07, 2026

Experienced / Intermediate

1070<p>The <em>MDS-AOS School for Device Aided Therapies in Parkinson&rsquo;s Disease</em> aims to cultivate the next generation of experts in DBS and infusion therapy for PD, providing them with a comprehensive overview, case-based discussion and hands-on workshop in DBS and infusion therapy in PD. This year's school will start with the basics and then discuss recent updates of DBS and infusion therapy in PD.<br /><br /><span style="color:#990000;"><strong>REGISTRATION DEADLINE: April 22, 2026</strong></span><strong></strong><strong></strong></p>Clinical Trials, Deep brain stimulation, Focused Ultrasound, Gene Therapies, Infusion therapy, Parkinson Disease/Hypokinetic Movement Disorders, Parkinson's Disease (PD), Therapies-Surgical6900.00https://education.movementdisorders.org/Detail/1070/MDS-AOS-School-for-Device-Aided-Therapies-in-Parkinson’s-Diseasehttps://education.movementdisorders.org/Upload/ActivityImages/26AOSNMOD_202x108589130.png2026-05-06T00:00:002026-05-07T00:00:00King Chulalongkorn Memorial Hospital, Bangkok<p><br></p><p><br></p>MDS Education<p><a href="https://d1t84l7yt030ad.cloudfront.net/FroalaFiles/26AOSNMOD Course Schedule_no faculty_10022026022546.pdf" rel="noopener noreferrer" target="_blank"><img src="https://s3-us-east-2.amazonaws.com/mds-lms/FroalaFiles/Course schedule_23012024043738.png" style="width: 125px; height: 125px;" class="fr-fic fr-dib"></a><strong>Course Schedule&nbsp;</strong><a href="https://form.jotform.com/260276276503154" rel="noopener noreferrer" target="_blank"><img src="https://s3-us-east-2.amazonaws.com/mds-lms/FroalaFiles/Travel assistance_23012024043912.png" style="width: 125px; height: 125px;" class="fr-fic fr-dib"></a><strong>Travel Bursary &nbsp; &nbsp; &nbsp; &nbsp;</strong><a href="https://d1t84l7yt030ad.cloudfront.net/FroalaFiles/Faculty Listing_LMS_CDs_11022026033320.pdf" rel="noopener noreferrer" target="_blank"><img src="https://s3-us-east-2.amazonaws.com/mds-lms/FroalaFiles/Faculty Details_23012024043924.png" style="width: 125px; height: 125px;" class="fr-fic fr-dib"></a><strong>Course Faculty</strong></p><p><br></p><p><em>Schedule as of February 10, 2026&nbsp;</em></p><p><strong><em><span style="color: rgb(175, 38, 38);">Travel Bursary Deadline:</span>&nbsp;</em></strong><em>February 27, 2026</em><br><br></p><p><strong>REGISTRATION FEES</strong><br><strong>Members:&nbsp;</strong>$200 USD<br><strong>Junior &amp; No-Fee Members:&nbsp;</strong>$150 USD<br><strong>Non-Members:&nbsp;</strong>$200 USD</p><p>*<em>Non-members wishing to apply for MDS Membership to receive the MDS Member rate for this course will need to apply for membership no later than 2 weeks in advance of the close of registration.</em></p><p><a href="https://s3-us-east-2.amazonaws.com/mds-lms/FroalaFiles/VISA%20STATEMENT%20CANCELLATION%20LANGUAGE_24012024041714.pdf">Click here to view the MDS Regional Course Cancellation Policy &amp; Visa Assistance Information</a></p><p><br></p><p><span style="background-color: null;"><strong>COURSE VENUE</strong></span></p><p>King Chulalongkorn Memorial Hospital</p><p>Bangkok, Thailand<br><br></p><p><strong>SCHEDULE OVERVIEW<em>&nbsp;</em></strong></p><p>Day 1: Wednesday, May 6, 2026 | 8:15 - 17:10<br>Day 2: Thursday, May 7, 2026 | 8:30 - 17:20</p><p><br></p><p><strong>LEARNING OBJECTIVES</strong></p><p>Upon completion of this activity, learners will be able to:&nbsp;</p><p>1. Develop the multi-disciplinary team for deep brain stimulation and infusion therapy</p><p>2. Classify the candidates of deep brain stimulation and infusion therapy</p><p>3. Compare the various targets for deep brain stimulation and choose the best target for subjects</p><p>4. Act initial programming and troubleshooting in patients with deep brain stimulation and those with infusion therapy</p><p>5. Act with deep brain stimulation programmer and infusion pump during hands-on workshops</p><p>6. Establish a local and international network of young clinicians and researchers, fostering collaborations and facilitating future research in the field of deep brain stimulation</p><p><br></p><p><strong>INTENDED AUDIENCE</strong></p><p>The target audience is clinicians, movement disorder specialists, fellows, neurology residents, clinical researchers, and clinical nurse specialists.<br><br></p>Bangkok0/Courses/School-for-Deep-Brain-Stimulation-and-Infusion-Therapy-in-Parkinsons-Disease.htmSchool for Device Aided Therapies in Parkinson’s Disease2026-01-29T12:01:06.52300Experienced / IntermediateIn-PersonParkinson Disease/Hypokinetic Movement DisordersTherapies-Surgical