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Tremor & Essential Tremor

Clinical Overviews

Essential Tremor

Essential tremor (ET) is the most common tremor syndrome seen in adults. Essential tremor is an isolated tremor syndrome of bilateral upper limb action tremor with at least 3 years’ duration, as recently defined by the MDS Task Force for Tremor. Tremor in other locations (e.g., head, voice, or lower limbs) may (or may not) be present. But there are no other neurological signs, such as dystonia, ataxia, or parkinsonism. To further clarify and to delineate ET from other tremors, exclusion criteria were also formulated: Thus, isolated focal tremors (voice, head), orthostatic tremor with a frequency >12 Hz, task- and position-specific tremors and sudden onset and step-wise deterioration do not fall into the category of ET.

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The characteristic tremor seen in ET is postural and action tremors, with a frequency of 4-7 Hz. These tremors may begin insidiously early in life, with an increment in tremor severity over the years. The disability in ET is associated with impairment of voluntary activities that occur as a result of the tremor. Patients commonly complain of tremors when eating, drinking and writing, spilling over food and drinks and developing a progressively illegible handwriting. The most commonly affected body parts include hands, head and voice, but may also be seen in the legs, trunk and face.

Despite being mainly a postural tremor, kinetic tremor may be present and sometimes a resting tremor of lesser severity may be appreciated. The tremor in ET is exacerbated by conditions as stress, exercise and fatigue, caffeine, certain medications and improves with relaxation and small doses of alcohol. Patients frequently have a family history.

The most common treatments for ET include: beta blockers such as proporanolol, primidone and topiramate. Sometimes, in medication-refractory tremor, deep brain stimulation of the VIM nucleus of the thalamus is considered.

 

Contributed by Hubert Fernandez, MD
Head, Movement Disorders
Department of Neurology
Cleveland Clinic
Cleveland, Ohio USA

Updated 2019: Contributed by Susan A. Schneider, MD
Consultant Neurologist
University Hospital Munchen
Pullach, Germany

Tremor

Tremor is an involuntary, rhythmic, oscillatory movement of a body part. Tremor results from contractions of agonist and antagonist muscles entrained by a signal pattern originating from an oscillator in the central nervous system. Resting tremor occurs in a body part that is not activated and completely supported against gravity. Action tremor refers to tremor occurring with voluntary muscle contraction and is subdivided into postural tremor, isometric tremor and kinetic tremor. The latter is further subdivided into simple kinetic, intention tremor, and task specific tremor, such as writing tremor.

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The etiology of tremor is diverse, and includes essential tremor (with 50% having a positive FH but no single gene identified); as part of genetic disorders eg Wilson’s disease;  degenerative such as Parkinson’s disease, Metabolic diseases (such as thyroid-, parathyroid-, liver disease and hypoglycemia); peripheral neuropathies (eg associated with Charcot-Marie-Tooth; drug-induced (including narcoleptics, tricyclics, lithium, cocaine, alcohol, adrenaline, bronchodilators, theophylline, caffeine, steroids, valproate, amiodarone, thyroid hormones, vincristine); toxins (heavy metals)  and psychogenic/functional disorders.

The original consensus criteria proposed by MDS from 1998 were recently revised to better overcome inconsistencies, particularly with regard to essential tremor (ET), tremor associated with dystonia or other additional neurological abnormalities, and focal tremors. The new consensus proposes classification has two main axes: clinical features (Axis 1) and etiology (Axis 2).

Clinically, a syndrome consisting only of tremor is called an isolated tremor syndrome. On the other hand, a syndrome of consisting of tremor and other systemic or neurological signs is called a combined tremor syndrome.

Etiologically, tremor can be classified into physiological tremor, enhanced physiological tremor, essential tremor syndromes (including classical ET), dystonic tremor, parkinsonian tremor, cerebellar tremor (often associated with multiple sclerosis), Holmes’ tremor (a.k.a. rubral tremor), palatal tremor, neuropathic tremor, toxic or drug-induced tremor, and psychogenic tremor.

 

Contributed by Leo Verhagen, MD, PhD
Associate Professor of Neurological Sciences
Rush University Medical Center
Chicago, IL, USA

2019 Updates Contributed by:

Susanne A. Schneider, MD
Consultant Neurologist
LMU University Hospital Muenchen
Munich, Germany

Susan Fox, MRCP (UK), PhD
Professor of Neurology
University of Toronto, Toronto Western Hospital
Toronto, ON, Canada

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Tremor Resources

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Latest Journal Articles

The latest tremor research published in Movement Disorders and Movement Disorders: Clinical Practice.

Tremor Study Group

MDS group working to develop the science and research on Tremor.

Evidence-Based Medicine Reviews

Read MDS's latest Evidence-Based Medicine Reviews about Tremor.

Patient Education

Handouts on movement disorder topics for physicians and patients, translated into multiple languages.

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Areas of Interest subtopics

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Latest Articles and Media on Tremor

Web article

Genetics of Essential Tremor

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  • Web article
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  • Genetics
  • Tremor/Essential Tremor (ET)

Podcast

Bilateral focused ultrasound thalamotomy for essential tremor, is it safe?

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  • Podcast
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  • Focused Ultrasound
  • Tremor/Essential Tremor (ET)

Web article

Technological Advances for Tremor Assessment

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  • Web article
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  • Tremor/Essential Tremor (ET)

Podcast

Tremor | Congress 2019

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  • Podcast
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  • Tremor/Essential Tremor (ET)

Podcast

The treatment of upper limb tremor with botulinum toxin: An individualized approach

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  • Podcast
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  • Botulinum toxin
  • Tremor/Essential Tremor (ET)

Podcast

Long-term outcomes of focused ultrasound in essential tremor

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  • Podcast
Areas of Interest subtopics
  • Focused Ultrasound
  • Tremor/Essential Tremor (ET)

Published paper

Consensus Statement on the classification of tremors: From the task force on tremor of the International Parkinson and Movement Disorder Society

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  • Tremor/Essential Tremor (ET)

Video

The enigma of action tremor in the elderly (2015)

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  • Tremor/Essential Tremor (ET)

Published paper

Task force report: Scales for screening and evaluating tremor: Critique and recommendations

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  • Published paper
Areas of Interest subtopics
  • Tremor/Essential Tremor (ET)

Tremor Education 

 

Fundamentals Course: Tremors (Other than PD)

This on-demand e-learning module provides an overview and description of the tremor syndromes, including essential tremor, enhanced physiologic tremor, Holmes tremor, dystonic tremor, etc.

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Tremor Curriculum Tracks

Curated sets of courses and materials that guide you progressively through Tremor topics.  

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Research Tools

Clinical Outcome Assessments

View clinical outcome assessments, including the Quality of Life in Essential Tremor Questionnaire (QUEST). 

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Video Case Library

Browse an archive of nearly 2,000 case videos and other multimedia. ✪ MEMBERS ONLY

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