MDS-Unified Parkinson's Disease Rating Scale (MDS-UPDRS)

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MDS-Sponsored Revision of the UPDRS (MDS-UPDRS)


Acronym: MDS-UPDRS

Authors: Christopher G. Goetz, Barbara Tilley, Stephanie R. Shaftman, Glenn T. Stebbins, Stanley Fahn, Pablo Martinez-Martin, Werner Poewe, Cristina Sampaio, Matthew B. Stern, Richard Dodel, Bruno Dubois, Robert Holloway, Joseph Jankovic, Jaime Kulisevsky, Anthony E. Lang, Andrew Lees, Sue Leurgans, Peter A. LeWitt, David Nyenhuis, C. Warren Olanow, Olivier Rascol, Anette Schrag, Jeanne A. Teresi, Jacobus J. van Hilten, Nancy LaPelle

The MDS-UPDRS is a revision of the Unified Parkinson’s Disease Rating Scale (UPDRS) originally developed in the 1980s. It addresses several problematic areas of the original scale identified by an MDS review task force. The MDS-UPDRS was developed to evaluate various aspects of Parkinson’s disease including non-motor and motor experiences of daily living and motor complications. It includes a motor evaluation and characterizes the extent and burden of disease across various populations. The scale can be used in a clinical setting as well as in research.

Original Publication │ View the Scale (PDF)

Notice: As of August 1, 2019 an update was made to item 3.17 (Rest Tremor) of the MDS-UPDRS. Following review of the scale, it was determined that several inequality symbols in the “Extremity Ratings” and “Lip/Jaw Ratings” were changed to provide consistency with the scoring for items 3.15 and 3.16. The effects of these changes are felt to be nominal. Clinical trials and other studies using the original 3.17 scoring may continue to do so for the duration of the study. For questions, please contact info@movementdisorders.org.

Year Published: 2008

Scale Last Updated: May 2, 2019

Assessment Type: ClinRO and PRO

Estimated Time to Administer the Scale: Under 30 minutes for full assessment (time for patient-reported outcomes may vary). 

Available Translations:

Additional Scale Publications:

Goetz CG, Fahn S, Martinez‐Martin P, Poewe W, Sampaio C, Stebbins GT, Stern MB, Tilley BC, Dodel R, Dubois B, Holloway R, et al. Movement Disorder Society‐Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS‐UPDRS): process, format, and clinimetric testing plan. Movement Disorders. 2007 Jan;22(1):41-7.

Goetz CG, Stebbins GT, Chmura TA, Fahn S, Poewe W, Tanner CM. Teaching program for the Movement Disorder Society‐Sponsored Revision of the Unified Parkinson's Disease Rating Scale:(MDS‐UPDRS). Movement Disorders. 2010 Jul 15;25(9):1190-4.

Martinez-Martin P, Rodriguez-Blazquez C, Alvarez-Sanchez M, Arakaki T, Bergareche-Yarza A, Chade A, Garretto N, Gershanik O, Kurtis MM, Martinez-Castrillo JC, Mendoza-Rodriguez A, Moore HP, Rodriguez-Violante M, Singer C, Tilley BC, Huang J, Stebbins GT, Goetz CG. Expanded and independent validation of the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS). J Neurol. 2013 Jan;260(1):228-36.

Stebbins GT, Goetz CG, Burn DJ, Jankovic J, Khoo TK, Tilley BC. How to identify tremor dominant and postural instability/gait difficulty groups with the Movement Disorder Society Unified Parkinson's Disease Rating Scale: Comparison with the Unified Parkinson's Disease Rating Scale. Movement Disorders. 2013 May;28(5):668-70.​

Rodriguez-Blazquez C, Rojo-Abuin JM, Alvarez-Sanchez M, Arakaki T, Bergareche-Yarza A, Chade A, Garretto N, Gershanik O, Kurtis MM, Martinez-Castrillo JC, Mendoza-Rodriguez A, Moore HP, Rodriguez-Violante M, Singer C, Tilley BC, Huang J, Stebbins GT, Goetz CG, Martinez-Martin P. The MDS-UPDRS Part II (Motor Experiences of Daily Living) resulted useful for assessment of disability in Parkinson’s Disease. Parkinsonism Relat Disord 2013 Oct;19(10):889-93.

Martínez-Martín P, Rodríguez-Blázquez C, Forjaz MJ, Álvarez-Sánchez M, Arakaki T, Bergareche-Yarza A, Chade A, Garretto N, Gershanik O, Kurtis MM, Martínez-Castrillo JC, Mendoza-Rodríguez A, Moore HP, Rodríguez-Violante M, Singer C, Tilley BC, Huang J, Stebbins GT, Goetz CG. Relationship between the MDS-UPDRS domains and the health-related quality of life of Parkinson’s disease patients. Eur J Neurol. 2014 Mar;21(3):519-24.

Goetz CG, Stebbins GT, Wang L, LaPelle NR, Lou S, Tilley BC.  IPMDS-sponsored scale translation program: process, format, and clinimetric testing plan for the MDS-UPDRS and UDysRS.  Movement Disorders Clinical Practice, 2014 May;1:97-101.

Goetz CG, Luo S, Wang L, Tilley BC, LaPelle NR, Stebbins GT. Handling missing values in the MDS‐UPDRS. Movement Disorders. 2015 Oct;30(12):1632-8.
Goetz CG, Liu Y, Stebbins GT, Wang L, Tilley BC, Teresi JA, Merkitch D, Luo S. Gender‐, age‐, and race/ethnicity‐based differential item functioning analysis of the Movement Disorder Society–Sponsored Revision of the Unified Parkinson's Disease Rating Scale. Movement Disorders. 2016 Dec;31(12):1865-73.​

Horváth K, Aschermann Z, Kovács M, Makkos A, Harmat M, Janszky J, Komoly S, Karádi K, Kovács N. Minimal clinically important differences for the experiences of daily living parts of Movement Disorder Society–Sponsored Unified Parkinson's Disease Rating Scale. Movement Disorders. 2017 May;32(5):789-93.

Martinez-Martin P, Skorvanek M, Rojo-Abuin JM, Gregova Z, Stebbins GT, Goetz CG; members of the QUALPD Study Group.  Validation study of the Hoehn and Yahr scale included in the MDS-UPDRS. Movement Disorders. 2018 Jan; 33(4): 651-652.

Skorvanek M, Martinez-Martin P, Kovacs N, Zezula I, Rodriguez-Violante M, Corvol JC, Taba P, Seppi K, Levin O, Schrag A, Aviles-Olmos I, Alvarez-Sanchez M, Arakaki T, Aschermann Z, Benchetrit E, Benoit C, Bergareche-Yarza A, Cervantes-Arriaga A, Chade A, Cormier F, Datieva V, Gallagher DA, Garretto N, Gdovinova Z, Gershanik O, Grofik M, Han V, Kadastik-Eerme L, Kurtis MM, Mangone G, Martinez-Castrillo JC, Mendoza-Rodriguez A, Minar M, Moore HP, Muldmaa M, Mueller C, Pinter B, Poewe W, Rallmann K, Reiter E, Rodriguez-Blazquez C, Singer C, Valkovic P, Goetz CG, Stebbins GT.  Relationship between the MDS-UPDRS and Quality of Life: A large multicenter study of 3206 patients.  Parkinsonism Relat Disord. 2018 July; 52:83-89.

 

 

 

 

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