Skip to Content


MDS makes every effort to publish accurate information on the website. "Google Translate" is provided as a free tool for visitors to read content in one's native language. Translations are not guaranteed to be 100% accurate. Neither MDS nor its employees assume liability for erroneous translations of website content.

International Parkinson and Movement Disorder Society
Main Content

        VOLUME 26, ISSUE 4 • DECEMBER 2022  Full issue »

Top Research Article, Movement Disorders

A multistep model of Parkinson’s disease pathogenesis 

Despite significant advances in our understanding of the aetiology of Parkinson’s disease (PD) spanning genetics, environmental exposures, infectious triggers, metabolic disruption and inflammatory and vascular contributions, an overarching framework for how the disease develops is lacking. Furthermore, basic observations such as incidence and prevalence differences between males and females do not have satisfactory explanations. A key question is whether the epidemiology of PD – and specifically how incidence varies with age – can tell us something fundamental about its pathogenesis. One possibility is that PD develops as a multistep process, involving cumulative, discrete events occurring over time and eventually leading to the development of the entity we recognise as Parkinson’s. If such a multistep process exists, then a linear relationship should exist between log(age) and log(incidence), with the slope of this line one less than the number of steps required for disease development. This model, termed the Armitage-Doll Model, has been extensively explored in the cancer literature and more recently applied to Amyotrophic lateral sclerosis.

In this study, we aimed to test the hypothesis that PD age-specific incidence is consistent with a multistep process, and to determine the number of discrete steps required to develop the disease. We then applied the multistep framework to three specific questions:  

  1. Is there evidence of a lower slope (and step number) at younger ages, which would be consistent with the greater contribution of genetic factors in those with younger-onset PD?  

  1. Do log-incidence curves for males and females differ in a manner consistent with varying environmental exposure effects or fundamentally different pathogenic mechanisms?  

  1. Can extensions of the basic Armitage-Doll model explain the observed fall in PD incidence at very old ages? 

We used a validated probabilistic modelling process, based on medication prescribing, to generate nationwide age- and sex-adjusted PD incidence data for New Zealand, spanning 2006-2017. Models of log(incidence) versus log(age) were compared using Bayes factors, to estimate (1) if a linear relationship was present (indicative of a multistep process); (2) the relationship's slope (one less than number of steps); (3) whether slope was lower at younger ages; and (4) whether slope or y-intercept varied with sex. Finally, extensions of the basic Armitage-Doll model were compared to determine if the fall in PD incidence at very old age was best explained by a competing age-related process, or depletion of an initial pool of people who could ever develop Parkinson’s disease.  

Across >15,000 incident cases of PD, there was a clear linear relationship between log(age) and log(incidence). Evidence was strongest for a model with an initial slope of 5.2 [3.8, 6.4], an inflexion point at age 45, and beyond this a slope of 6.8 [6.4, 7.2] There was evidence for the intercept varying by sex, but no evidence for slope being sex-dependent. A model with an initial pool of people (11% males, 7% females) who could ever develop PD best explained the observed late-age decline in incidence. The work shows that the age-specific incidence of PD is consistent with a pathogenic process that develops in multiple, discrete steps – on average six before age 45 and eight after. The model supports theories emphasizing the primacy of environmental factors in driving sex differences in PD incidence, whilst also suggesting that only a proportion of the population are susceptible to ever developing Parkinson’s disease. The multistep model may form a unifying framework within which ongoing research on pathogenesis can be understood. 

The MDS Podcast delved more into this paper and its processes in an interview with the author:   

Listen now » 


Read more Moving Along:

Full issue  Archives

We use cookies to give you the best possible experience with our website. These cookies are also used to ensure we show you content that is relevant to you. If you continue without changing your settings, you are agreeing to our use of cookies to improve your user experience. You can click the cookie settings link on our website to change your cookie settings at any time. Note: The MDS site uses related multiple domains, including and This cookie policy only covers the primary and domain. Please refer to the MDS Privacy Policy for information on how to configure cookies for all other domains on the MDS site.
Cookie PolicyPrivacy Notice