Skip to Content


MDS makes every effort to publish accurate information on the website. "Google Translate" is provided as a free tool for visitors to read content in one's native language. Translations are not guaranteed to be 100% accurate. Neither MDS nor its employees assume liability for erroneous translations of website content.

International Parkinson and Movement Disorder Society
Main Content

Multiple System Atrophy: Essential Facts for Patients

What Is It?

Multiple System Atrophy (MSA) is a rare disorder that affects the functioning of multiple systems in the brain. Some of these are involved in the control of movement, balance and coordination, while others ensure blood pressure, bladder, bowel and sexual function.

Patients may experience:

  • Slowness of movement, muscle stiffness and/or shaking/tremor
  • Problems with balance and coordination
  • Feeling lightheaded or dizzy while standing
  • Problems controlling bladder function and constipation

MSA is one type of Atypical Parkinsonism. Atypical Parkinsonism, also called Parkinson-plus syndrome, is when the patient has some of the main features of Parkinson’s disease (PD) such as slowness of movement, muscle stiffness and/or shaking/tremor, as well as some other features. Patients with slowness, muscle stiffness or shaking may resemble patients with PD and are called MSA-P. Patients who have more difficulty with balance and coordination are called MSA-C.

These disorders were formerly known as:

  • MSA: Shy-Drager syndrome
  • MSA-P: striatonigral degeneration (SND)
  • MSA-C: sporadic olivopontocerebellar atrophy (OPCA)

Who Gets MSA?

MSA affects men and women equally. MSA usually begins between the age of 50 and 60. MSA is considered rare and affects around three to four people in every 100,000.

What Is the Cause?

The cause is unknown. MSA is associated with accumulation of a protein in the brain called alpha-synuclein that clumps up in different cell types and can be seen in a brain autopsy. The cause of this clumping is unknown. MSA has been described in a few families, but is currently not considered a hereditary disease. MSA is not contagious or spread from person to person.

How Is MSA Diagnosed?

A diagnosis may not be clear at first. MSA is usually diagnosed based on symptoms and physical examination findings. Tests may include brain MRI scan, bladder tests, and testing for blood pressure changes, including the table tilt-test.

No single test can confirm the diagnosis. The only definite way to confirm the diagnosis of MSA is by doing an autopsy and looking at the brain tissue.

Is There a Treatment?

There are currently no treatments to cure, slow down or reverse MSA. However, some medications and physical therapies may help your symptoms.

Parkinson-like symptoms of slowness, stiffness, and tremor may improve with medications typically used for PD.

Low blood pressure when moving into a sitting or standing position (orthostatic hypotension) may improve by avoiding triggers like alcohol, dehydration, and heat or hot temperatures. You may need to adjust or stop medications for other illnesses, especially those that might lower blood pressure. Doctors may advise increasing water and salt intake or using abdominal bandages or pressure stockings. In addition, specific medications may help increase blood pressure. Stable blood pressure helps you avoid unsteadiness, lightheadedness, and dizziness that contribute to falling or balance problems.

For bladder and bowel problems, options include medications, regular toileting, bladder training, and catheterization.

Drooling can be treated with medications and botulinum toxin injections into the saliva glands.

Overall health may also benefit from physical therapy, occupational therapy, or speech and swallowing therapy.

What Can I Expect as I Live With MSA?

Over time, symptoms increase and treatments become less effective. You may experience difficulties using utensils, swallowing solid food or liquids, walking and controlling bladder or bowels.

In advanced stages, MSA patients have increased risk of infections. Bladder symptoms can lead to urinary tract infections. Swallowing problems increase the risk of pneumonia. Overall, long-term care planning may be needed as the disease progresses.


Copyright © 2018 International Parkinson and Movement Disorder Society (MDS).  All rights reserved.


View these essential facts in a variety of languages. 



Please wait while we gather your results.

Multiple System Atrophy (MSA) (Arabic)

  • Alarabia (ألعربيه ) - Arabic

Multiple System Atrophy (MSA) (Dutch)

  • Nederlands - Dutch

Multiple System Atrophy (MSA) (Bangla)

  • বাংলা - Bangla

Multiple System Atrophy (MSA) (Estonian)

  • Eesti keel - Estonian

Multiple System Atrophy (MSA) (Bulgarian)

  • български - Bulgarian

Multiple System Atrophy (MSA) (French)

  • Français - French

Multiple System Atrophy (MSA) (Croatian)

  • Hrvatski - Croatian

Multiple System Atrophy (MSA) (Czech)

  • Čeština - Czech

Multiple System Atrophy (MSA) (Greek)

  • ελληνικά - Greek

Multiple System Atrophy (MSA) (Hebrew)

  • עברית - Hebrew

We use cookies to give you the best possible experience with our website. These cookies are also used to ensure we show you content that is relevant to you. If you continue without changing your settings, you are agreeing to our use of cookies to improve your user experience. You can click the cookie settings link on our website to change your cookie settings at any time. Note: The MDS site uses related multiple domains, including and This cookie policy only covers the primary and domain. Please refer to the MDS Privacy Policy for information on how to configure cookies for all other domains on the MDS site.
Cookie PolicyPrivacy Notice