Normal Pressure Hydrocephalus (NPH) Study Group





Alfonso Fasano





Joachim Krauss

MDS Staff Liaison: Ken Buesing


Elissa Ash, Tel Aviv Medical Center, Israel

Bastiaan R. Bloem, Radboud University, the Netherlands

Brent R. Bluett, Stanford Movement Disorders Center, USA

Araceli Alonso Canovas, Hospital Ramón y Cajal, Spain

Roberto Ceravolo, University of Pisa, Italy

Alberto Espay, University of Cincinnati, USA

Victor Fung, University of Sydney, Australia

Neill Graff-Radford, Mayo Clinic Jacksonville, USA

Mark Hamilton, University of Calgary, Canada

Anthony E. Lang, University of Toronto, Canada

Neil Mahant, Westmead Hospital, Australia

Davide Martino, Calgary University, Canada

Aristide Merola, The Ohio State University Wexner Medical Center, USA

Giovanni Mostile, University of Catania, Italy

Sean Nagel, Cleveland Clinic, USA

Claudio Pacchetti, Istituto Mondino, Italy

Andy Parrent, University of Western Ontario, Canada

Philippe Rizek, University of Toronto, Canada

Katarzyna Smilowska, Radboud University Medical Center, Poland

Carmela Tartaglia, University of Toronto, Canada

Alessandro Tessitore, University of Campania Luigi Vanvitelli, Italy

Michele Tinazzi, University of Verona, Italy

Mwiza Ushe, Washington University School of Medicine, USA

Louis Verret, Centre Pôle Santé Sud, Canada

David Tang-Wai, University of Toronto, Canada

Bob Wharen, Mayo Clinic, USA

Carsten Wikkelso, Sahlgrenska University Hospital, Sweden

Michael A. Williams, University of Washington, USA

Jinyoung Youn, Samsung Medical Center, South Korea

Mario Zappia, University of Catania, Italy



Normal Pressure Hydrocephalus (NPH) is a still obscure condition, relatively frequent but historically not addressed by Movement Disorders (MDS) publications or conferences. Most patients with NPH present with gait disorders at onset (often in isolation) and often the differential diagnosis includes Parkinson's disease, progressive supranuclear palsy or higher level gait disorders caused by vascular brain diseases. Recently, the pathophysiology and real existence of NPH has been questioned, thus starting a debate among NPH experts and movement disorders neurologists. For these reasons the time has come for the International Parkinson and Movement Disorder Society (MDS) to establish a study group on NPH.

Unmet Needs

  • Lack of standardized assessments to inform diagnosis and differential diagnosis (e.g. gold standard for procedures such as transient CSF shunting – tap tests or external lumbar drainage, neuroimaging, gait analysis, etc.)
  • Lack of collaborative research efforts
  • Lack of defined research goals (e.g. role of CSF biomarkers, surgical outcome predictors, pathological findings, double-blind clinical trials)
  • Lack of communication between IPDMDS and other societies

The study group will function as a ‘round table’ for neurologists with interest in phenomenology (particularly gait and balance), neuropsychologists, neurosurgeons as well as scientists involved in neurodegenerative diseases. Particular attention will be given to aspects related to our field of movement disorders, such type of freezing of gait displayed by NPH patients, clinical and pathophysiological meaning of L-dopa responsiveness or abnormal dopamine imaging. The study group is open to considering new members interested in NPH.



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