MDS Non-Motor Symptoms - Questionnaire (MDS-NMS-Q)

The MDS-NMS-Q is a self-completed, simplified (focusing on severity only) questionnaire version of the rater-administered MDS-NMS, developed and validated for use in Parkinson’s disease (PD).

The main instrument of the MDS-NMS-Q is a 13-domain, 52-item instrument covering the most commonly-reported non-motor symptoms in Parkinson’s disease. There is also a separate, non-motor fluctuations (NMFs) subscale covering 8 commonly-reported NMFs occurring in the context of PD medication wearing “off” periods. In the validation study, data quality was satisfactory for all 13 MDS-NMS-Q domains. There were no floor or ceiling effects for the total score; individual domains had no appreciable ceiling effects but variable floor effects. Internal consistency for most domains was satisfactory, except for the impulse control domain. Correlation and concordance between MDS-NMS-Q and MDS-NMS total scores were high. Thus, the MDS-NMS-Q has a strong association and concordance with the MDS-NMS at the total score and domain level. This indicates that the MDS-NMS-Q, allowing self-completion and focusing only on symptom severity, is an acceptable alternative to the rater- administered MDS-NMS.  

Authors: K. Ray Chaudhuri, MDAnette Schrag, PhDDaniel Weintraub, MDAlexandra Rizos, MScPablo Martinez-Martin, MD, PhD

Original Publication │View the Scale (PDF)

• Acronym: MDS-NMS-Q
• Year Published: 2021
• Scale Last Updated: No updates since publication
• Estimated Time to Complete: 10 minutes
• Assessment Type: PRO
• Available translations: None